Nov. 13th 2018 - Christy Ford Chapin, PhD - Who Determines How Medicine is Practiced?: A History of Physicians, Insurance Companies, and the U.S. Health Care System
MilwaukeeAcademy of Medicine
Tuesday,October 16th, 2018
900 W. Wisconsin Avenue
COCKTAILS 6:00 P.M. DINNER 6:30 P.M. AWARD and PRESENTATION 7:30 P.M.
2018 Distinguished Achievement Award
How a Large Database of “Real World” Clinical Data Improved the Outcomes of Blood and Bone Marrow Transplantation
Mary M. Horowitz, MD, MS
Chief Scientific Director, CIBMTR®,
Robert A. Uihlein, Jr. Chair in Hematologic Research, Department of Medicine
Froedtert and the Medical College of Wisconsin Clinical Cancer Center
The Center for International Blood and Marrow Transplant Research (CIBMTR) began collecting and analyzing clinical data on hematopoietic stem cell transplants in 1972, just 4 years after the first successful bone marrow transplants were done. Over the past four decades, data from this outcomes registry has led to changes that both expanded access to this therapy and increased survival. Linking these data with analyses of bio-specimens and using it to plan and implement clinical trials provided some of the most impactful and practice-changing information for the field. As tools to collect and analyze large amounts of data become both more sophisticated and more accessible, lessons from the CIBMTR on how to use real world data to advance science and clinical care are increasingly relevant.
Describe the history of blood and marrow transplantation (BMT) and its use as a therapy for malignant and non-malignant blood disorders and other diseases.
Describe the role of analyzing real world data in advancing clinical applications of BMT.
Describe how real world data can inform the design, implementation and interpretation of clinical trials.
Dr. Horowitz earned her MD in 1980 and an MS in biostatistics/clinical epidemiology in 1991 from the Medical College of Wisconsin (MCW). She joined the Center for International Blood and Marrow Transplant Research (CIBMTR) in 1985, and has served as its Chief Scientific Director since 1991. The CIBMTR maintains a large outcomes registry that captures clinical data on donors and recipients of hematopoietic stem cell transplants (HCTs) in 40 countries. It is also collecting long-term follow data on recipients of non-transplant cellular therapies, including CAR-T-cells. It also operates a large repository of donor-recipient biospecimens linked to its clinical data. The CIBMTR brings together investigators from hundreds of institutions to facilitate 70-80 peer-reviewed publications annually that focus on clinical and immunobiologic determinants of transplant outcomes. Dr. Horowitz is also Research Director for the Stem Cell Therapeutic Outcomes Database of the C.W. Bill Young Cell Transplantation Program (charged with collecting and analyzing outcomes data on all allogeneic HCTs in the U.S.) and Principal Investigator of the Data and Coordinating Center of the national Blood and Marrow Transplant Clinical Trials Network. The latter is an NIH-funded national network conducting Phase II and III trials focused on transplantation and cellular therapy. She holds the Robert A. Uihlein Professorship for Hematologic Research at MCW and is an active BMT physician. In 2010, Dr. Horowitz was awarded the American Society of Hematology Mentor Award for Clinical Science for her work promoting the training and career development of young investigators. In 2013 she was inducted into the American Association of Physicians and in 2014 was selected to receive the American Society of Blood and Marrow Transplantation’s Lifetime Achievement Award. She has been continuously funded by the United States National Institutes of Health since 1991 and has co-authored more than 350 peer-reviewed publications.
Please make dinner reservations for this meeting no later than the Thursday before the meeting.
Reservations received after the above deadline will be accommodated, but an alternate dinner entrée may be substituted.
Menu Options – Select One Entree: Beef, Chicken, Salmon
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This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of The Medical College of Wisconsin and Milwaukee Academy of Medicine. The Medical College of Wisconsin is accredited by the ACCME to provide continuing medical education for physicians.
AMA Credit Designation Statement:
The Medical College of Wisconsin designates this Live Activity for a maximum of 1 AMA PRA Category 1 Credit(s) ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Please make dinner reservations for this meeting no later than the Thursday prior to the meeting. Reservations can be made by email: email@example.com or by phone 414/456-8249. There is a charge for dinners reserved unless cancelled by the Thursday prior to the meeting.